Publication
Title
Diarylquinolines target subunit c of mycobacterial ATP synthase
Author
Abstract
The diarylquinoline R207910 (TMC207) is a promising candidate in clinical development for the treatment of tuberculosis. Though R207910-resistant mycobacteria bear mutations in ATP synthase, the compound's precise target is not known. Here we establish by genetic, biochemical and binding assays that the oligomeric subunit c (AtpE) of ATP synthase is the target of R207910. Thus targeting energy metabolism is a new, promising approach for antibacterial drug discovery.
Language
English
Source (journal)
Nature chemical biology. - New York
Publication
New York : Nature Publishing Group, 2007
ISSN
1552-4450
Volume/pages
3:6(2007), p. 323-324
ISI
000246816400010
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 13.03.2009
Last edited 24.06.2017
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