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Title
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Diarylquinolines target subunit c of mycobacterial ATP synthase
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Author
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Abstract
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| The diarylquinoline R207910 (TMC207) is a promising candidate in clinical development for the treatment of tuberculosis. Though R207910-resistant mycobacteria bear mutations in ATP synthase, the compound's precise target is not known. Here we establish by genetic, biochemical and binding assays that the oligomeric subunit c (AtpE) of ATP synthase is the target of R207910. Thus targeting energy metabolism is a new, promising approach for antibacterial drug discovery. |
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Language
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English
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Source (journal)
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Nature chemical biology / Nature Publishing Group. - New York
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Publication
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New York
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Nature Publishing Group
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2007
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ISSN
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1552-4450
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DOI
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10.1038/NCHEMBIO884
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Volume/pages
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3
:6
(2007)
, p. 323-324
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ISI
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000246816400010
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Full text (Publisher's DOI)
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