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Title
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In vitro antimycobacterial spectrum of a diarylquinoline ATP synthase inhibitor
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Author
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Abstract
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| The diarylquinoline R207910 is in clinical development for tuberculosis treatment. The MIC50 for 41 drug-susceptible and 44 multidrug-resistant Mycobacterium tuberculosis clinical isolates was 0.032 µg/ml. Out of 20 additional mycobacterial species, three were found to be naturally resistant to R207910 and were shown to exhibit a polymorphism in their atpE genes. |
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Language
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English
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Source (journal)
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Antimicrobial agents and chemotherapy. - Washington, D.C., 1972, currens
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Publication
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Washington, D.C.
:
American Society for Microbiology
,
2007
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ISSN
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0066-4804
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DOI
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10.1128/AAC.00181-07
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Volume/pages
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51
:11
(2007)
, p. 4202-4204
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ISI
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000250612900062
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Full text (Publisher's DOI)
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