Title
|
|
|
|
In vitro antimycobacterial spectrum of a diarylquinoline ATP synthase inhibitor
|
|
Author
|
|
|
|
|
|
Abstract
|
|
|
|
The diarylquinoline R207910 is in clinical development for tuberculosis treatment. The MIC50 for 41 drug-susceptible and 44 multidrug-resistant Mycobacterium tuberculosis clinical isolates was 0.032 µg/ml. Out of 20 additional mycobacterial species, three were found to be naturally resistant to R207910 and were shown to exhibit a polymorphism in their atpE genes. |
|
|
Language
|
|
|
|
English
|
|
Source (journal)
|
|
|
|
Antimicrobial agents and chemotherapy. - Washington, D.C., 1972, currens
|
|
Publication
|
|
|
|
Washington, D.C.
:
American Society for Microbiology
,
2007
|
|
ISSN
|
|
|
|
0066-4804
|
|
DOI
|
|
|
|
10.1128/AAC.00181-07
|
|
Volume/pages
|
|
|
|
51
:11
(2007)
, p. 4202-4204
|
|
ISI
|
|
|
|
000250612900062
|
|
Full text (Publisher's DOI)
|
|
|
|
|
|