Publication
Title
Human hereditary hearing impairment: mouse models can help to solve the puzzle
Author
Abstract
Mouse models are important research tools in the discovery of genes for syndromic as well as non-syndromic forms of hearing impairment. The similarity between the human and mouse inner ear, as well as the high homology between the human and mouse genome, make the mouse an excellent tool for genetic research on hearing loss. Over the past ten years, multiple mouse models for human hereditary hearing loss have been identiWed. The current review discusses the models according to the biological process in which they are involved. We review mouse models for genes involved in acellular matrix composition, hair bundle formation and maintenance, outer hair cell electromotility, the hair cell ribbon synapse and auditory nerve transmission, regulation of cochlear homeostasis and regulation of transcription. We have opted to put most emphasis on mouse models for non-syndromic forms of human hearing loss. However, we also discuss advances made in the Weld of age related hearing impairment by the use of mouse models and modiWers of hearing loss genes identiWed in mice
Language
English
Source (journal)
Human genetics. - Berlin
Publication
Berlin : 2008
ISSN
0340-6717
Volume/pages
124:4(2008), p. 325-348
ISI
000260767100001
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 18.03.2009
Last edited 10.07.2017
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