Publication
Title
Does hypothalamicpituitaryadrenal axis hypofunction in chronic fatigue syndrome reflect a crash in the stress system?
Author
Abstract
The etiopathogenesis of chronic fatigue syndrome (CFS) remains poorly understood. Although neuroendocrine disturbances and hypothalamicpituitaryadrenal (HPA) axis hypofunction in particular have been found in a large proportion of CFS patients, it is not clear whether these disturbances are cause or consequence of the illness. After a review of the available evidence we hypothesize that that HPA axis hypofunction in CFS, conceptualized within a system-biological perspective, primarily reflects a fundamental and persistent dysregulation of the neurobiological stress system. As a result, a disturbed balance between glucocorticoid and inflammatory signaling pathways may give rise to a pathological cytokine-induced sickness response that may be the final common pathway underlying central CFS symptoms, i.e. effort/stress intolerance and pain hypersensitivity. This comprehensive hypothesis on HPA axis hypofunction in CFS may stimulate diagnostic refinement of the illness, inform treatment approaches and suggest directions for future research, particularly focusing on the neuroendocrineimmune interface and possible links between CFS, early and recent life stress, and depression.
Language
English
Source (journal)
Medical hypotheses. - Edinburgh
Publication
Edinburgh : 2009
ISSN
0306-9877
Volume/pages
72:6(2009), p. 701-705
ISI
000265474100022
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 01.04.2009
Last edited 17.06.2017
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