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Title
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Early endothelial dysfunction in young type 1 diabetics
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Author
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Abstract
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| Objectives Endothelial dysfunction is a known precursor of atherosclerosis and can be assessed by measuring the brachial artery flow-mediated dilatation (FMD) via ultrasonography. This study investigated endothelial function in young type 1 diabetics without cardiovascular morbidity or diabetes-related pathology. Methods Young diabetics and healthy controls were recruited, both meeting strict inclusion and exclusion criteria. To prove absence of subclinical atherosclerosis, intima-media thickness (IMT) measurements at the carotid bifurcation were done in all of them. FMD was measured at the brachial artery. The results were compared using the t-test and the influences of different variables on FMD were assessed using multiple linear regression. Results Twenty-six diabetics (23.4 ¡À 5.8 years) and 36 healthy volunteers (23.1 ¡À 2.8 years) were recruited. The duration of diabetes was 9.2 ¡À 5.3 years; metabolic control was moderate (HbA1c 7.6 ¡À 1.0%) and IMT was normal in both groups. FMD was significantly impaired in type 1 diabetics (7.13 ¡À 0.43 vs. 8.77 ¡À 0.43%; p = 0.002). The FMD grade was associated with diabetes and age. Patients with a good metabolic control (HbA1c ¡Ü 7.0%) had a better FMD. Conclusions In type 1 diabetics, even without preclinical or clinical atherosclerosis, endothelial function is already disturbed and can be detected using ultrasonography. |
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Language
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English
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Source (journal)
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European journal of vascular and endovascular surgery. - London
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Publication
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London
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2009
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ISSN
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1078-5884
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DOI
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10.1016/J.EJVS.2009.01.015
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Volume/pages
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37
:5
(2009)
, p. 611-615
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ISI
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000266139200019
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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