Title
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Genetic variation in the **KIF1B** locus influences susceptibility to multiple sclerosis
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Author
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Abstract
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The few loci associated with multiple sclerosis (MS) are all related to immune function. We report a GWA study identifying a new locus replicated in 2,679 cases and 3,125 controls. An rs10492972[C] variant located in the KIF1B gene was associated with MS with an odds ratio of 1.35 (P = 2.5 10-10). KIF1B is a neuronally expressed gene plausibly implicated in the irreversible axonal loss characterizing MS in the long term. |
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Language
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English
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Source (journal)
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Nature genetics. - New York, N.Y.
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Publication
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New York, N.Y.
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2008
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ISSN
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1061-4036
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DOI
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10.1038/NG.251
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Volume/pages
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40
:12
(2008)
, p. 1402-1403
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ISI
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000261215900013
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Full text (Publisher's DOI)
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