|
Title
|
|
|
|
Genetic variation in the **KIF1B** locus influences susceptibility to multiple sclerosis
| |
|
Author
|
|
|
|
| |
|
Abstract
|
|
|
|
| The few loci associated with multiple sclerosis (MS) are all related to immune function. We report a GWA study identifying a new locus replicated in 2,679 cases and 3,125 controls. An rs10492972[C] variant located in the KIF1B gene was associated with MS with an odds ratio of 1.35 (P = 2.5 10-10). KIF1B is a neuronally expressed gene plausibly implicated in the irreversible axonal loss characterizing MS in the long term. |
| |
|
Language
|
|
|
|
English
| |
|
Source (journal)
|
|
|
|
Nature genetics. - New York, N.Y.
| |
|
Publication
|
|
|
|
New York, N.Y.
:
2008
| |
|
ISSN
|
|
|
|
1061-4036
| |
|
DOI
|
|
|
|
10.1038/NG.251
| |
|
Volume/pages
|
|
|
|
40
:12
(2008)
, p. 1402-1403
| |
|
ISI
|
|
|
|
000261215900013
| |
|
Full text (Publisher's DOI)
|
|
|
|
| |
|