Exposure of the elderly to potential nephrotoxic drug combinations in Belgium
Faculty of Medicine and Health Sciences
Pharmacoepidemiology and drug safety. - Chichester, 1992, currens
, p. 1014-1019
University of Antwerp
Purpose To count in the Belgian ambulatory prescription database Pharmanet, the number of elderly people treated with ACE inhibitors (ACEI) and/or angiotensine receptor blockers (ARB) (±diuretics ± -blockers) who eventually also received a prescription of non-steroidal anti-inflammatory drugs (NSAID) or spironolactone. Method All prescriptions dispensed in community pharmacies are collected in the Pharmanet database. The data of 2005 were used. Two age groups were studied: 65-79 years (label 1) and 80+ years (label 2). The following chronic treatments (subgroups) were studied: (A) ACEI/ARB; (B) ACEI/ARB + diuretics; (C) ACEI/ARB + spironolactone; (D) ACEI/ARB + -blocker + diuretic and (E) ACEI/ARB + -blocker + spironolactone. Results In 2005, 7.3% of Belgian population was chronically treated with ACEI/ARB. Twenty-five per cent of 65-79 year-old-patients (subgroup A1) and 36.15% of 80+ year-old-patients (subgroup A2) received ACEI/ARB. At least one package of NSAID or spironolactone was prescribed to subgroup A1 in 25.44 and 5.80%, respectively, and to subgroup A2 in 22.04 and 9.89%, respectively. In all studied subgroups and age categories, NSAID were coprecribed in more than 20-35% of cases. Conclusions NSAID are frequently prescribed in elderly patients treated with ACEI or ARB in combination with diuretics. Severe renal adverse effects may result in this high-risk population.