Title
Exposure of the elderly to potential nephrotoxic drug combinations in Belgium Exposure of the elderly to potential nephrotoxic drug combinations in Belgium
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Chichester ,
Subject
Pharmacology. Therapy
Source (journal)
Pharmacoepidemiology and drug safety. - Chichester, 1992, currens
Volume/pages
17(2008) :10 , p. 1014-1019
ISSN
1053-8569
ISI
000260094000009
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Purpose To count in the Belgian ambulatory prescription database Pharmanet, the number of elderly people treated with ACE inhibitors (ACEI) and/or angiotensine receptor blockers (ARB) (±diuretics ± -blockers) who eventually also received a prescription of non-steroidal anti-inflammatory drugs (NSAID) or spironolactone. Method All prescriptions dispensed in community pharmacies are collected in the Pharmanet database. The data of 2005 were used. Two age groups were studied: 65-79 years (label 1) and 80+ years (label 2). The following chronic treatments (subgroups) were studied: (A) ACEI/ARB; (B) ACEI/ARB + diuretics; (C) ACEI/ARB + spironolactone; (D) ACEI/ARB + -blocker + diuretic and (E) ACEI/ARB + -blocker + spironolactone. Results In 2005, 7.3% of Belgian population was chronically treated with ACEI/ARB. Twenty-five per cent of 65-79 year-old-patients (subgroup A1) and 36.15% of 80+ year-old-patients (subgroup A2) received ACEI/ARB. At least one package of NSAID or spironolactone was prescribed to subgroup A1 in 25.44 and 5.80%, respectively, and to subgroup A2 in 22.04 and 9.89%, respectively. In all studied subgroups and age categories, NSAID were coprecribed in more than 20-35% of cases. Conclusions NSAID are frequently prescribed in elderly patients treated with ACEI or ARB in combination with diuretics. Severe renal adverse effects may result in this high-risk population.
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