Publication
Title
Improved discrimination of autopsy-confirmed Alzheimer's disease (AD) from non-AD dementias using CSF P-
Author
Abstract
To establish diagnostic accuracy (acc) and optimal cut-off levels of CSF tau phosphorylated at threonine 181 (P-tau181P) for discriminating Alzheimer's disease (AD) from non-AD dementias in autopsy-confirmed dementia patients, CSF levels of â-amyloid peptide (Aâ142), total tau protein (T-tau) and P-tau181P from patients with definite AD (n = 95) and non-AD dementias (n = 50) were determined with single-parameter ELISA kits. Optimal P-tau181P cut-off levels for differentiating AD from pooled non-AD dementias, dementia with Lewy bodies (DLB) and frontotemporal dementia (FTD) were 50.4 pg/mL (acc = 0.73), 52.8 pg/mL (acc = 0.73) and 35.3 pg/mL (acc = 0.90), respectively. The optimal CSF P-tau181P cut-off level for discriminating AD from non-AD dementias was 50.4 pg/mL. Optimal CSF P-tau181P cut-off levels differed between non-AD diagnostic dementia categories.
Language
English
Source (journal)
Neurochemistry international. - Oxford
Publication
Oxford : 2009
ISSN
0197-0186
Volume/pages
55:4(2009), p. 214-218
ISI
000267839600006
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 14.04.2009
Last edited 31.10.2017
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