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Title
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Improved discrimination of autopsy-confirmed Alzheimer's disease (AD) from non-AD dementias using CSF P-
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Author
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Abstract
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| To establish diagnostic accuracy (acc) and optimal cut-off levels of CSF tau phosphorylated at threonine 181 (P-tau181P) for discriminating Alzheimer's disease (AD) from non-AD dementias in autopsy-confirmed dementia patients, CSF levels of â-amyloid peptide (Aâ142), total tau protein (T-tau) and P-tau181P from patients with definite AD (n = 95) and non-AD dementias (n = 50) were determined with single-parameter ELISA kits. Optimal P-tau181P cut-off levels for differentiating AD from pooled non-AD dementias, dementia with Lewy bodies (DLB) and frontotemporal dementia (FTD) were 50.4 pg/mL (acc = 0.73), 52.8 pg/mL (acc = 0.73) and 35.3 pg/mL (acc = 0.90), respectively. The optimal CSF P-tau181P cut-off level for discriminating AD from non-AD dementias was 50.4 pg/mL. Optimal CSF P-tau181P cut-off levels differed between non-AD diagnostic dementia categories. |
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Language
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English
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Source (journal)
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Neurochemistry international. - Oxford
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Publication
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Oxford
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2009
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ISSN
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0197-0186
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DOI
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10.1016/J.NEUINT.2009.02.017
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Volume/pages
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55
:4
(2009)
, p. 214-218
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ISI
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000267839600006
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Full text (Publisher's DOI)
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