Publication
Title
R75761, a lead compound for the development of antiviral drugs in late stage poliomyelitis eradication strategies and beyond
Author
Abstract
In this study the antiviral activity of a panel of 18 out of 240 pyridazinamine analogues was evaluated against the Sabin strains of the three poliovirus types. We found one compound, R75761 which had a comparable 50% effective concentration (EC50) value against all three poliovirus Sabin strains. Virus multiplication was reduced by 104.0-fold, 106.2-fold and 106.6-fold for poliovirus type 1, type 2 and type 3, respectively. R75761 could be considered as a lead compound for development of anti-poliovirus drugs to be used during the late stage of poliovirus eradication and beyond.
Language
English
Source (journal)
Antiviral research. - Amsterdam
Publication
Amsterdam : 2008
ISSN
0166-3542
Volume/pages
78:3(2008), p. 278-281
ISI
000255383300013
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
External links
Web of Science
Record
Identification
Creation 16.04.2009
Last edited 23.06.2017