Title
Potential use of antiviral agents in polio eradication Potential use of antiviral agents in polio eradication
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Publication type
article
Publication
Atlanta, Ga ,
Subject
Pharmacology. Therapy
Source (journal)
Emerging infectious diseases / National Center for Infectious Diseases. Centers for Disease Control and Prevention. - Atlanta, Ga
Volume/pages
14(2008) :4 , p. 545-551
ISSN
1080-6040
ISI
000254595000002
Carrier
E
Target language
English (eng)
Abstract
In 1988, the World Health Assembly launched the Global Polio Eradication Initiative, which aimed to use large-scale vaccination with the oral vaccine to eradicate polio worldwide by the year 2000. Although important progress has been made, polio remains endemic in several countries. Also, the current control measures will likely be inadequate to deal with problems that may arise in the postpolio era. A panel convoked by the National Research Council concluded that the use of antiviral drugs may be essential in the polio eradication strategy. We here report on a comparative study of the antipoliovirus activity of a selection of molecules that have previously been reported to be inhibitors of picornavirus replication and discuss their potential use, alone or in combination, for the treatment or prophylaxis of poliovirus infection.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/e9c37c/6879207a.pdf
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