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Title
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Is vitamin D deficiency involved in the immune reconstitution inflammatory syndrome?
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Author
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Abstract
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| Background About 20-30% of persons with HIV infection, especially those living in countries with limited resources, experience an immune reconstitution inflammatory syndrome (IRIS) after starting antiretroviral treatment. The active form of vitamin D, 1,25-dihydroxyvitamin D, is a key player in clearance of pathogens and influences the level of inflammation and macrophage activation. Presentation of the hypothesis We hypothesize that low availability of 1,25-dihydroxyvitamin D, either due to vitamin D deficiency or to polymorphisms in vitamin D receptor or its activating/inactivating enzymes, contributes to the appearance of IRIS. Furthermore, drug interactions with vitamin D enzymatic pathways could favour the development of IRIS. Testing the hypothesis Our hypothesis could be explored by a case-control study to assess the prevalence of vitamin D deficiency in HIV-infected patients on antiretroviral treatment who develop and do not develop IRIS. Implications of the hypothesis If the role of vitamin D in IRIS is confirmed, we would be able to screen patients at risk for IRIS by screening for vitamin D deficiency. After confirmation by means of a clinical trial, vitamin D supplementation could be a cheap and safe way to reduce the incidence of IRIS. |
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Language
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English
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Source (journal)
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Aids research and therapy. - London
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Publication
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London
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2009
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ISSN
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1742-6405
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Volume/pages
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6
(2009)
, p. 4,1-4,18
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Full text (Publisher's DOI)
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Full text (open access)
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