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Title
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Comparison of three immunoassays and one GC-MS method for the determination of valproic acid
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Author
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Abstract
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| The antiepileptic drug valproic acid shows good therapeutic efficacy when plasma concentrations range between 50 and 100 ìg/ml. Because higher concentrations may induce toxicity, monitoring of valproic acid plasma concentrations is a frequently performed assay in the routine clinical laboratory. The authors compared their routine fluorescence polarisation immunoassay on the Cobas Integra 400 with a competitive immunoassay, a cloned enzyme donor immunoassay, both on the Vitros Fusion 5.1 chemistry system, and a gas chromatographic procedure with mass detection of the trimethylsilyl derivative of valproic acid. |
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Language
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English
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Source (journal)
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Immuno-analyse et biologie specialisée. - Paris
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Publication
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Paris
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2008
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ISSN
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0923-2532
[print]
1878-1365
[online]
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DOI
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10.1016/J.IMMBIO.2008.01.004
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Volume/pages
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23
:4
(2008)
, p. 240-244
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ISI
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000260406900006
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Full text (Publisher's DOI)
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