Title
Comparison of three immunoassays and one GC-MS method for the determination of valproic acid Comparison of three immunoassays and one GC-MS method for the determination of valproic acid
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Publication type
article
Publication
Subject
Pharmacology. Therapy
Source (journal)
Immuno-analyse et biologie specialisée
Volume/pages
23(2008) :4 , p. 240-244
ISSN
0923-2532
ISI
000260406900006
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
The antiepileptic drug valproic acid shows good therapeutic efficacy when plasma concentrations range between 50 and 100 ìg/ml. Because higher concentrations may induce toxicity, monitoring of valproic acid plasma concentrations is a frequently performed assay in the routine clinical laboratory. The authors compared their routine fluorescence polarisation immunoassay on the Cobas Integra 400 with a competitive immunoassay, a cloned enzyme donor immunoassay, both on the Vitros Fusion 5.1 chemistry system, and a gas chromatographic procedure with mass detection of the trimethylsilyl derivative of valproic acid.
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