Publication
Title
Comparison of three immunoassays and one GC-MS method for the determination of valproic acid
Author
Abstract
The antiepileptic drug valproic acid shows good therapeutic efficacy when plasma concentrations range between 50 and 100 ìg/ml. Because higher concentrations may induce toxicity, monitoring of valproic acid plasma concentrations is a frequently performed assay in the routine clinical laboratory. The authors compared their routine fluorescence polarisation immunoassay on the Cobas Integra 400 with a competitive immunoassay, a cloned enzyme donor immunoassay, both on the Vitros Fusion 5.1 chemistry system, and a gas chromatographic procedure with mass detection of the trimethylsilyl derivative of valproic acid.
Language
English
Source (journal)
Immuno-analyse et biologie specialisée
Publication
2008
Volume/pages
23:4(2008), p. 240-244
ISI
000260406900006
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 29.04.2009
Last edited 18.06.2017
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