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Title
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Influence of chitosan layer on the properties of surface modified poly(lactide-co-glycolide) nanoparticles
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Author
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Abstract
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| The present study investigates the effect of chitosan coating layer on the properties of poly(lactic-co-glycolic acid) nanoparticles. Two concentrations of chitosan (0.1% and 0.5%) as well as two procedures, namely coating or post-coating were developed. The size of all chitosan modified particles was larger than the size of nonmodified PLGA-nanoparticles. The surface charge of the modified nanoparticles was positive (up to +57.0 mV) compared to the negative charge of PLGA-nanoparticles (-23.6 mV). The positive charge of all types of the modified particles decreased drastically 6 hours after incubation with a mucin, suggesting the electrostatic mechanism of their interaction. |
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Language
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English
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Source (journal)
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Journal of dispersion science and technology. - New York, N.Y.
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Publication
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New York, N.Y.
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2009
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ISSN
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0193-2691
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DOI
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10.1080/01932690802498666
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Volume/pages
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30
:2
(2009)
, p. 213-216
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ISI
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000262859400012
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Full text (Publisher's DOI)
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