Title
Influence of chitosan layer on the properties of surface modified poly(lactide-co-glycolide) nanoparticles Influence of chitosan layer on the properties of surface modified poly(lactide-co-glycolide) nanoparticles
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Publication type
article
Publication
New York, N.Y. ,
Subject
Pharmacology. Therapy
Source (journal)
Journal of dispersion science and technology. - New York, N.Y.
Volume/pages
30(2009) :2 , p. 213-216
ISSN
0193-2691
ISI
000262859400012
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
The present study investigates the effect of chitosan coating layer on the properties of poly(lactic-co-glycolic acid) nanoparticles. Two concentrations of chitosan (0.1% and 0.5%) as well as two procedures, namely coating or post-coating were developed. The size of all chitosan modified particles was larger than the size of nonmodified PLGA-nanoparticles. The surface charge of the modified nanoparticles was positive (up to +57.0 mV) compared to the negative charge of PLGA-nanoparticles (-23.6 mV). The positive charge of all types of the modified particles decreased drastically 6 hours after incubation with a mucin, suggesting the electrostatic mechanism of their interaction.
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