Publication
Title
Influence of chitosan layer on the properties of surface modified poly(lactide-co-glycolide) nanoparticles
Author
Abstract
The present study investigates the effect of chitosan coating layer on the properties of poly(lactic-co-glycolic acid) nanoparticles. Two concentrations of chitosan (0.1% and 0.5%) as well as two procedures, namely coating or post-coating were developed. The size of all chitosan modified particles was larger than the size of nonmodified PLGA-nanoparticles. The surface charge of the modified nanoparticles was positive (up to +57.0 mV) compared to the negative charge of PLGA-nanoparticles (-23.6 mV). The positive charge of all types of the modified particles decreased drastically 6 hours after incubation with a mucin, suggesting the electrostatic mechanism of their interaction.
Language
English
Source (journal)
Journal of dispersion science and technology. - New York, N.Y.
Publication
New York, N.Y. : 2009
ISSN
0193-2691
Volume/pages
30:2(2009), p. 213-216
ISI
000262859400012
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 06.05.2009
Last edited 18.06.2017
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