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Title
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Impact of HIV-1 infection on the hematological recovery after clinical malaria
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Author
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Abstract
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| Background: Anemia is the most frequent cytopenia in HIV-infected individuals and is often associated with malaria. Objective: To assess the impact of HIV-1 on the hematological recovery after a clinical malaria episode. Methods: In Ndola, Zambia, a region with high malaria and HIV prevalence, hemoglobin (Hb) was measured in 634 malaria patients 14 and 45 days after antimalarial treatment. Risk factors for hematological recovery were analyzed in a multivariate linear regression model. Results: At enrollment, HIV-1-infected malaria patients had lower Hb compared with HIV-1 uninfected (122.7 vs 136.0 g/L; P < 0.001). In both groups, mean Hb was significantly lower at day 14 posttreatment than day 0 (P < 0.0001) and significantly higher at day 45 than at day 14 (HIV-1 negative: P = 0.0001; HIV-1 infected: P = 0.005). HIV-1 was a risk factor for a larger Hb decrease until day 14 (P < 0.001) and slower recovery until day 45 (P = 0.048). When considering the whole 45-day follow-up period, mean Hb increased in the HIV-1-negative group (+3.54 g/L; 95% confidence interval: 1.37 to 5.70; P = 0.001) but not in the HIV-1-infected group (-0.72 g/L; 95% confidence interval: -3.85 to +2.40; P = 0.64). HIV-1 infection as such (P < 0.0001), not CD4 cell count (P = 0.46), was an independent risk factor for a slower hematological recovery. Conclusions: HIV-1-infected malaria patients had a slower hematological recovery after successful parasite clearance. Malaria preventive measures should be targeted to this high-risk group. |
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Language
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English
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Source (journal)
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JAIDS. - Philadelphia, Pa
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Publication
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Philadelphia, Pa
:
2009
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ISSN
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1525-4135
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DOI
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10.1097/QAI.0B013E3181900159
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Volume/pages
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50
:2
(2009)
, p. 200-205
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ISI
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000262878700012
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Full text (Publisher's DOI)
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