Title
Structure, dynamics and function of **Leishmania** genome: resolving the puzzle of infection, genetics and evolution? Structure, dynamics and function of **Leishmania** genome: resolving the puzzle of infection, genetics and evolution?
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
Amsterdam ,
Subject
Human medicine
Source (journal)
Infection, genetics and evolution. - Amsterdam
Volume/pages
9(2009) :2 , p. 290-297
ISSN
1567-1348
ISI
000264049400020
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
We review and discuss here the specificity and contribution of genome (re-)arrangement studies for the exploration of genetic diversity among Leishmania. We show how the early molecular karyotyping studies generated an original perception of the genetics and evolution of these Protozoa, while providing some possible explanations on the parasite diverse phenotypes (drug resistance, pathogenicity). We compare the results with the enormous amount of data provided by the recent genome sequencing projects, so far focused on one strain per genus/species. We highlight the relevance of parallel sequencing of different strains of a same species, now made possible by the new sequencing technologies. We recommend paying a particular attention to variation in gene copy number, a feature showed by the karyotyping studies to be extremely informative.
E-info
https://repository.uantwerpen.be/docman/iruaauth/883c8f/df002561c4e.pdf
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