Title
Evaluation of different techniques to create chronic urinary incontinence in the rat Evaluation of different techniques to create chronic urinary incontinence in the rat
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Oxford ,
Subject
Veterinary medicine
Human medicine
Source (journal)
BJU international / British Association of Urological Surgeons. - Oxford, 1999, currens
Volume/pages
103(2009) :6 , p. 782-785
ISSN
1464-4096
ISI
000263600300014
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
To evaluate models for chronic urinary incontinence (UI) in the rat. MATERIALS AND METHODS Two models were fully evaluated: one of repeated dilatation of the vagina, simulating birth trauma, the vaginal dilatation (VD) group; the other, with surgical transposition of the urethra to a vertical position, the urethral transposition (UT) group. The VD rats were evaluated by the sneeze test. When negative, vaginal dilatation was repeated in a similar way. The UT group was evaluated by observation of continuous urine leakage. The leak-point pressure (LPP) was measured at study end in all the rats. RESULTS All the VD rats had occasional negative sneeze tests and all had to be dilated again. This resulted in persistent UI on sneeze testing for the entire period. In the UT group, 12 rats leaked continuously during the whole study period; in the other four UI became less at 4, 5, 6, and 7 weeks, respectively. The LPP in the rats with UI was significantly lower than in the respective control groups. CONCLUSIONS These models permit study of chronic stress UI and continuous UI in the rat. Spontaneous recovery of continence was seen mostly in the VD group.
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