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Title
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Comparison of three ELISAs for the routine diagnosis of human T-lymphotropic virus infection in a high-prevalence setting in Peru
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Author
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Abstract
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| To compare three human T-lymphotropic virus (HTLV) ELISAs in a high-prevalence setting, we recruited 300 adults: 125 relatives of HTLV-infected subjects and 175 patients with possible diagnoses of HTLV-associated diseases. Sera were tested with Platelia, Murex, and Ortho ELISA. Samples with positive or discordant ELISA underwent confirmatory Inno-Lia testing. Inno-Lia gave 85/300 HTLV-1-positive and 1/300 HTLV-2-positive results. The positive predictive value was 98% for Platelia, and 100% for Murex and Ortho. Six samples had discordant ELISA; Murex gave one false-negative result, Ortho two and Platelia one. In high-prevalence settings, it is recommended to test samples with two ELISAs before considering them HTLV-seronegative. |
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Language
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English
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Source (journal)
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Transactions of the Royal Society of Tropical Medicine and Hygiene. - London
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Publication
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London
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2009
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ISSN
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0035-9203
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DOI
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10.1016/J.TRSTMH.2008.12.002
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Volume/pages
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103
:4
(2009)
, p. 420-422
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ISI
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000264976700018
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Full text (Publisher's DOI)
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