Title
Furosemide in preterm infants treated with indomethacin for patent ductus arteriosus
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Oslo ,
Subject
Human medicine
Source (journal)
Acta paediatrica. - Oslo, 1992, currens
Volume/pages
98(2009) :5 , p. 797-803
ISSN
0803-5253
1651-2227
ISI
000264878100009
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Objective: To evaluate the effect of furosemide on renal function and water balance in preterm infants treated with indomethacin (3 × 0.2 mg/kg at 12-h intervals) for symptomatic patent ductus arteriosus. Patients and Methods: We performed a retrospective multi-centre double cohort study in preterm infants <32 weeks of gestational age. Thirty-two infants treated with furosemide (1 mg/kg i.v.) before each indomethacin dose (furosemide group) were matched with 32 infants with indomethacin treatment alone (control-group). Renal effects (urine output, weight gain, serum creatinine, sodium concentration) were registered. Results: The study groups were comparable for gestational age, birth weight and day of therapy. Pretreatment differences were observed for urine output, weight and serum sodium. However, no differences were noticed in day-to-day urine output change or weight gain between the groups. A significant increase in serum creatinine concentration (50% vs. control, 18%; p < 0.05) and a concomitant significant decrease in serum sodium (9 vs. control, 3 mmoL/L; p < 0.05) in the furosemide group was observed 7296 h after starting therapy. Conclusion: Furosemide before each indomethacin dose resulted in a significant increase in serum creatinine and hyponatremia, without increasing urine output.
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