Title
Can the use of different parameters and waveforms improve the results of intravesical electrical stimulation: a pilot study in the rat Can the use of different parameters and waveforms improve the results of intravesical electrical stimulation: a pilot study in the rat
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
New York ,
Subject
Human medicine
Source (journal)
Neurourology and urodynamics. - New York
Volume/pages
28(2009) :3 , p. 246-250
ISSN
0733-2467
ISI
000264698500020
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Aim Intravesical electrical stimulation (IVES) with square wave pulses, low frequencies and short pulse durations has been used for decades in diagnosis and treatment of lower urinary tract dysfunction. The results are not always satisfying. Several parameters have been studied before but not the use of other waveforms and the effect of electrical charge. This study compares the effect of changing waveforms, frequencies, pulse durations, amplitudes and derived parameters in IVES. Methods IVES, performed in seven female Sprague-Dawley rats, was given for 10 sec with constant current unipolar square or sawtooth pulses with different pulse durations (10, 20, or 100 msec), frequencies (5, 20, or 10 Hz) and amplitudes (2, 4, 6, and 8mA). Bladder pressure was recorded. Electrical charge and power were calculated. Results Stimulation with the same frequency, same pulse duration and same amplitude showed significantly higher maximal pressure rises (max P) for square wave (all P < 0.05). Stimulation with the same frequency, same pulse duration and same electrical charge, gave no different max P for both waveforms (all P > 0.05). The charge and power could be reduced without changing max P, by lowering frequencies and/or shortening pulse durations. Conclusions Sawtooth pulses are equally effective as square pulses for inducing detrusor contraction during IVES with the same electric charge. Frequency and pulse duration had, in this study, a minor influence on the efficacy of IVES. Lower frequency and/or shorter pulse duration results in lower charge and power without changing stimulation efficacy. This finding can be important for the battery life of implanted stimulators and for patient's comfort.
E-info
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000264698500020&DestLinkType=RelatedRecords&DestApp=ALL_WOS&UsrCustomerID=ef845e08c439e550330acc77c7d2d848
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000264698500020&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=ef845e08c439e550330acc77c7d2d848
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000264698500020&DestLinkType=CitingArticles&DestApp=ALL_WOS&UsrCustomerID=ef845e08c439e550330acc77c7d2d848
Handle