Title
In situ dissolution testing using potentiometric sensorsIn situ dissolution testing using potentiometric sensors
Author
Faculty/Department
Faculty of Sciences. Chemistry
Research group
Chromatographic Organic Trace Analysis
Publication type
article
Publication
Amsterdam,
Subject
Chemistry
Pharmacology. Therapy
Source (journal)
European journal of pharmaceutical sciences. - Amsterdam, 1993, currens
Volume/pages
34(2008):4/5, p. 243-249
ISSN
0928-0987
ISI
000258489900005
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Potentiometric sensors can be used to determine the amount of API dissolved in the dissolution medium in function of time by measuring directly in the dissolution vessel of a Paddle (USP type 2) and Basket (USP type 1) apparatus. The prototype potentiometric sensor instrumentation showed very promising results for a selection of APIs with different physico-chemical properties. The applicability, benefits and limitations of the prototype were explored. The applicability of the measurement technique strongly depends on the log(P) of the API. Here, it is shown that measurements can easily be performed for APIs with a log(P) > 4. Electrode performance however decreases with decreasing log P of the APIs due to decreased drug selectivity in comparison to the excipients and ionic strength of the applied dissolution medium. The potentiometric sensors are shown to be insensitive towards undissolved particles and air bubbles as opposed to UV spectrometric measurement where these can lead to severe light scattering. For the tested APIs, the obtained dissolution profiles are very reproducible and show a low variation compared to the measurements using manual sampling and UV or HPLC analysis. The measurements demonstrate that potentiometric sensors are a very promising technology that can become a standard for in situ dissolution measurements.
E-info
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