Title
Exercise-induced biphasic increase in circulating NT-proBNP levels in patients with chronic heart failureExercise-induced biphasic increase in circulating NT-proBNP levels in patients with chronic heart failure
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Research group
Translational Pathophysiological Research (TPR)
Publication type
article
Publication
,
Subject
Human medicine
Source (journal)
European journal of heart failure. -
Volume/pages
10(2008):8, p. 793-795
ISSN
1388-9842
1879-0844
ISI
000258556700010
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Background: Exercise increases natriuretic peptide levels in chronic heart failure (CHF) patients, but the effect is considered minor. We assessed acute and short-term release (< 24 h) of NT-proBNP in CHF patients after a maximal cardiopulmonary exercise test (CPET) and 2 different submaximal training sessions. Methods and results: 102 CHF patients either performed CPET (Group 1), a I It endurance (Group 2) or a combined endurance-resistance training session (Group 3). NT-proBNP concentration was determined before, at exercise cessation and after 18-22 h (Protocol A). In 20 patients, samples were obtained before, at exercise cessation, after 15, 30, 45, 60, 90 min, 2, 3, 4, 5, 6, 12, 22 h (Protocol B). Protocol A: At peak exercise, a 15%, 11% and 17% relative increase (p < 0.001 vs baseline, all 3 groups) was seen, with a return to baseline after 18-22 h. The increase correlated with indicators of more advanced heart failure. Protocol B: A biphasic pattern was derived with a first peak within 1 h of exercise termination and a second peak (39%, 31% and 33% higher than baseline; p < 0.05, all 3 groups) after 4-12 h. Conclusions: The observed biphasic release of B-type natriuretic peptides supports standardization of sampling, taking recent exercise into account.
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