Title
Possibilities and limits of X-ray microtomography for in vivo and ex vivo detection of vascular calcifications Possibilities and limits of X-ray microtomography for in vivo and ex vivo detection of vascular calcifications
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Faculty of Medicine and Health Sciences
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
Boston, Mass. ,
Subject
Human medicine
Source (journal)
The international journal of cardiovascular imaging. - Boston, Mass.
Volume/pages
25(2009) :6 , p. 615-624
ISSN
1569-5794
ISI
000269152800009
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
In the present paper, vascular calcifications due to chronic renal failure in rats are studied by X-ray microtomography (ì-CT). Although ì-CT is traditionally used as an imaging technique, a quantitative analysis of data obtained by in vivo and ex vivo ì-CT is described and discussed. By comparison with traditional destructive methods, such as histomorphometry and atomic absorption, the detection limits for calcium were determined in living rats and in extracted aortas. ì-CT proved to be an effective non-invasive imaging technique allowing non-destructive quantification of ectopic calcifications.
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