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Title
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Low levels of second-line drug resistance among multidrug-resistant **Mycobacterium tuberculosis** isolates from Rwanda
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Author
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Abstract
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| Background Multidrug-resistant tuberculosis (MDR-TB) has become a therapeutic problem in many parts of the world, necessitating the inclusion of second-line anti-tuberculosis drugs in specific treatment regimens. Methods We studied the susceptibility of 69 MDR Mycobacterium tuberculosis isolates from Rwanda to second-line drugs by the BACTEC 460 method. Results The results showed that 62 (89.9%) were resistant to rifabutin while a low rate (4.3%) of resistance was registered for ofloxacin; there was one case (1.4%) of resistance each for para-aminosalicylic acid, kanamycin, ethionamide, and clarithromycin. Conclusions This information is important for devising an appropriate treatment regimen for MDR-TB patients in order to stop the spread of MDR strains and contain the acquisition of additional drug resistance in Rwanda. |
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Language
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English
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Source (journal)
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International journal of infectious diseases / International Society for Infectious Diseases. - Hamilton, Ont.
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Publication
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Hamilton, Ont.
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2008
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ISSN
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1201-9712
1878-3511
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DOI
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10.1016/J.IJID.2007.05.003
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Volume/pages
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12
:2
(2008)
, p. 152-156
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ISI
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000253854100010
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Full text (Publisher's DOI)
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