Title
|
|
|
|
Low levels of second-line drug resistance among multidrug-resistant **Mycobacterium tuberculosis** isolates from Rwanda
| |
Author
|
|
|
|
| |
Abstract
|
|
|
|
Background Multidrug-resistant tuberculosis (MDR-TB) has become a therapeutic problem in many parts of the world, necessitating the inclusion of second-line anti-tuberculosis drugs in specific treatment regimens. Methods We studied the susceptibility of 69 MDR Mycobacterium tuberculosis isolates from Rwanda to second-line drugs by the BACTEC 460 method. Results The results showed that 62 (89.9%) were resistant to rifabutin while a low rate (4.3%) of resistance was registered for ofloxacin; there was one case (1.4%) of resistance each for para-aminosalicylic acid, kanamycin, ethionamide, and clarithromycin. Conclusions This information is important for devising an appropriate treatment regimen for MDR-TB patients in order to stop the spread of MDR strains and contain the acquisition of additional drug resistance in Rwanda. |
| |
Language
|
|
|
|
English
| |
Source (journal)
|
|
|
|
International journal of infectious diseases / International Society for Infectious Diseases. - Hamilton, Ont.
| |
Publication
|
|
|
|
Hamilton, Ont.
:
2008
| |
ISSN
|
|
|
|
1201-9712
1878-3511
| |
DOI
|
|
|
|
10.1016/J.IJID.2007.05.003
| |
Volume/pages
|
|
|
|
12
:2
(2008)
, p. 152-156
| |
ISI
|
|
|
|
000253854100010
| |
Full text (Publisher's DOI)
|
|
|
|
| |
|