Publication
Title
HTLV-1 infection is associated with a history of active tuberculosis among family members of HTLV-1-infected patients in Peru
Author
Abstract
The purpose of this study was to assess the association between human T-lymphotropic virus 1 (HTLV-1) and a lifetime history of active tuberculosis (TB) among relatives of HTLV-1-infected patients. We reviewed clinical charts of all relatives of HTLV-1-infected index cases who attended our institute in Lima from 19902004. The data of 1233 relatives was analysed; 394 (32·0%) were HTLV-1 positive. Eighty-one subjects (6·6%) had a history of active TB, including 45/394 (11·4%) HTLV-1-positive and 36/839 (4·3%) HTLV-1-negative relatives (P<0·001). On multivariate analysis, three factors were associated with TB history: HTLV-1 infection (adjusted OR 2·5, 95% CI 1·63·9), age (adjusted OR 1·3, 95% CI 1·11·5 per 10-year age increase) and relation to the index case (adjusted OR 2·6, 95% CI 1·35·1, for siblings vs. spouses of index cases). In conclusion, HTLV-1 infection may increase the susceptibility to active TB. In populations where both infections are frequent, such an association could affect the dynamics of TB.
Language
English
Source (journal)
Epidemiology and infection. - London, 1987, currens
Publication
London : 2008
ISSN
0950-2688 [print]
1469-4409 [online]
Volume/pages
136:8(2008), p. 1076-1083
ISI
000259748200008
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 09.06.2009
Last edited 09.10.2017
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