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Title
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HTLV-1 infection is associated with a history of active tuberculosis among family members of HTLV-1-infected patients in Peru
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Author
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Abstract
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| The purpose of this study was to assess the association between human T-lymphotropic virus 1 (HTLV-1) and a lifetime history of active tuberculosis (TB) among relatives of HTLV-1-infected patients. We reviewed clinical charts of all relatives of HTLV-1-infected index cases who attended our institute in Lima from 19902004. The data of 1233 relatives was analysed; 394 (32·0%) were HTLV-1 positive. Eighty-one subjects (6·6%) had a history of active TB, including 45/394 (11·4%) HTLV-1-positive and 36/839 (4·3%) HTLV-1-negative relatives (P<0·001). On multivariate analysis, three factors were associated with TB history: HTLV-1 infection (adjusted OR 2·5, 95% CI 1·63·9), age (adjusted OR 1·3, 95% CI 1·11·5 per 10-year age increase) and relation to the index case (adjusted OR 2·6, 95% CI 1·35·1, for siblings vs. spouses of index cases). In conclusion, HTLV-1 infection may increase the susceptibility to active TB. In populations where both infections are frequent, such an association could affect the dynamics of TB. |
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Language
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English
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Source (journal)
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Epidemiology and infection. - London, 1987, currens
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Publication
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London
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2008
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ISSN
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0950-2688
[print]
1469-4409
[online]
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Volume/pages
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136
:8
(2008)
, p. 1076-1083
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ISI
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000259748200008
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Full text (Publisher's DOI)
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