Title
HTLV-1 infection is associated with a history of active tuberculosis among family members of HTLV-1-infected patients in Peru HTLV-1 infection is associated with a history of active tuberculosis among family members of HTLV-1-infected patients in Peru
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Publication type
article
Publication
London ,
Subject
Human medicine
Source (journal)
Epidemiology and infection. - London, 1987, currens
Volume/pages
136(2008) :8 , p. 1076-1083
ISSN
0950-2688
1469-4409
ISI
000259748200008
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
The purpose of this study was to assess the association between human T-lymphotropic virus 1 (HTLV-1) and a lifetime history of active tuberculosis (TB) among relatives of HTLV-1-infected patients. We reviewed clinical charts of all relatives of HTLV-1-infected index cases who attended our institute in Lima from 19902004. The data of 1233 relatives was analysed; 394 (32·0%) were HTLV-1 positive. Eighty-one subjects (6·6%) had a history of active TB, including 45/394 (11·4%) HTLV-1-positive and 36/839 (4·3%) HTLV-1-negative relatives (P<0·001). On multivariate analysis, three factors were associated with TB history: HTLV-1 infection (adjusted OR 2·5, 95% CI 1·63·9), age (adjusted OR 1·3, 95% CI 1·11·5 per 10-year age increase) and relation to the index case (adjusted OR 2·6, 95% CI 1·35·1, for siblings vs. spouses of index cases). In conclusion, HTLV-1 infection may increase the susceptibility to active TB. In populations where both infections are frequent, such an association could affect the dynamics of TB.
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