Title
Antiplasmodial and other constituents from four Indonesian **Garcinia** spp. Antiplasmodial and other constituents from four Indonesian **Garcinia** spp.
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Publication type
article
Publication
Oxford ,
Subject
Chemistry
Biology
Pharmacology. Therapy
Source (journal)
Phytochemistry: an international journal of plant biochemistry. - Oxford
Volume/pages
70(2009) :7 , p. 907-912
ISSN
0031-9422
ISI
000268386700010
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Phytochemical investigations of four Garcinia spp. from Indonesia, i.e. Garcinia griffithii T. Anderson, Garcinia celebica L., Garcinia cornea L. and Garcinia cymosa K. Schum (Clusiaceae), have resulted in the isolation of a xanthone, 1,5-dihydroxy-3,6-dimethoxy-2,7-diprenylxanthone, 1,7-dihydroxyxanthone, isoxanthochymol, â-sitosterol-3-O-â-d-glucoside and stigmasterol-3-O-â-d-glucoside from the stem bark of G. griffithii; friedelin and 3â-hydroxy-23-oxo-9,16-lanostadien-26-oic acid or garcihombronane D from leaves of G. celebica; 23-hydroxy-3-oxo-cycloart-24-en-26-oic acid and epicatechin from stem bark of G. cornea; (±)-morelloflavone, morelloflavone-7-O-â-d-glucoside or fukugiside, the triterpene 3â-hydroxy-5-glutinen-28-oic acid and canophyllol from stem bark of G. cymosa. The xanthone and garcihombronane D displayed a selective activity against Plasmodium falciparum; isoxanthochymol and the triterpene â-hydroxy-5-glutinen-28-oic acid a broad but non-selective antiprotozoal activity.
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