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Title
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Antiplasmodial and other constituents from four Indonesian **Garcinia** spp.
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Author
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Abstract
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| Phytochemical investigations of four Garcinia spp. from Indonesia, i.e. Garcinia griffithii T. Anderson, Garcinia celebica L., Garcinia cornea L. and Garcinia cymosa K. Schum (Clusiaceae), have resulted in the isolation of a xanthone, 1,5-dihydroxy-3,6-dimethoxy-2,7-diprenylxanthone, 1,7-dihydroxyxanthone, isoxanthochymol, â-sitosterol-3-O-â-d-glucoside and stigmasterol-3-O-â-d-glucoside from the stem bark of G. griffithii; friedelin and 3â-hydroxy-23-oxo-9,16-lanostadien-26-oic acid or garcihombronane D from leaves of G. celebica; 23-hydroxy-3-oxo-cycloart-24-en-26-oic acid and epicatechin from stem bark of G. cornea; (±)-morelloflavone, morelloflavone-7-O-â-d-glucoside or fukugiside, the triterpene 3â-hydroxy-5-glutinen-28-oic acid and canophyllol from stem bark of G. cymosa. The xanthone and garcihombronane D displayed a selective activity against Plasmodium falciparum; isoxanthochymol and the triterpene â-hydroxy-5-glutinen-28-oic acid a broad but non-selective antiprotozoal activity. |
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Language
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English
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Source (journal)
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Phytochemistry: an international journal of plant biochemistry. - Oxford
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Publication
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Oxford
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2009
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ISSN
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0031-9422
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DOI
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10.1016/J.PHYTOCHEM.2009.04.024
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Volume/pages
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70
:7
(2009)
, p. 907-912
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ISI
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000268386700010
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Full text (Publisher's DOI)
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