Publication
Title
Best practices for hybridization design in two-colour microarray analysis
Author
Abstract
Two-colour microarrays are a popular platform of choice in gene expression studies. Because two different samples are hybridized on a single microarray, and several microarrays are usually needed in a given experiment, there are many possible ways to combine samples on different microarrays. The actual combination employed is commonly referred to as the hybridization design. Different types of hybridization designs have been developed, all aimed at optimizing the experimental setup for the detection of differentially expressed genes while coping with technical noise. Here, we first provide an overview of the different classes of hybridization designs, discussing their advantages and limitations, and then we illustrate the current trends in the use of different hybridization design types in contemporary research.
Language
English
Source (journal)
Trends in biotechnology : regular edition. - Amsterdam, 1983, currens
Publication
Amsterdam : 2009
ISSN
1879-3096 [online]
0167-7799 [print]
Volume/pages
27:7(2009), p. 406-414
ISI
000268087000004
Full text (Publishers DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 25.06.2009
Last edited 18.05.2017
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