Title
Complementary DNA sequences encoding the multimammate rat MHC class II DQ <tex>$\alpha$</tex> and <tex>$\beta$</tex> chains and cross-species sequence comparison in rodents Complementary DNA sequences encoding the multimammate rat MHC class II DQ <tex>$\alpha$</tex> and <tex>$\beta$</tex> chains and cross-species sequence comparison in rodents
Author
Faculty/Department
Faculty of Sciences. Biology
Publication type
article
Publication
KÝbenhavn ,
Subject
Biology
Source (journal)
Tissue antigens: histocompatibility and immunogenetics. - KÝbenhavn
Volume/pages
74(2009) :3 , p. 233-237
ISSN
0001-2815
ISI
000268714200006
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Sequences of the complete open reading frame (ORF) for rodents major histocompatibility complex (MHC) class II genes are rare. Multimammate rat (Mastomys natalensis) complementary DNA (cDNA) encoding the a and b chains of MHC class II DQ gene was cloned from a rapid amplifications of cDNA Emds (RACE) cDNA library. The ORFs consist of 801 and 771 bp encoding 266 and 256 amino acid residues for DQB and DQA, respectively. The genomic structure of Mana-DQ genes is globally analogous to that described for other rodents except for the insertion of a serine residue in the signal peptide of Mana-DQB, which is unique among known rodents.
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