Publication
Title
TGF- 1-induced migration of bone mesenchymal stem cells couples bone resorption with formation
Author
Abstract
Bone remodeling depends on the precise coordination of bone resorption and subsequent bone formation. Disturbances of this process are associated with skeletal diseases, such as Camurati-Engelmann disease (CED). We show using in vitro and in vivo models that active TGF-1 released during bone resorption coordinates bone formation by inducing migration of bone marrow stromal cells, also known as bone mesenchymal stem cells, to the bone resorptive sites and that this process is mediated through a SMAD signaling pathway. Analyzing mice carrying a CED-derived mutant TGFB1 (encoding TGF-1), which show the typical progressive diaphyseal dysplasia seen in the human disease, we found high levels of active TGF-1 in the bone marrow. Treatment with a TGF- type I receptor inhibitor partially rescued the uncoupled bone remodeling and prevented the fractures. Thus, as TGF-1 functions to couple bone resorption and formation, modulation of TGF-1 activity could be an effective treatment for bone remodeling diseases.
Language
English
Source (journal)
Nature medicine. - London, 1995, currens
Publication
London : 2009
ISSN
1078-8956 [print]
1546-170X [online]
Volume/pages
15:7(2009), p. 757-765
ISI
000267806900028
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 25.08.2009
Last edited 09.10.2017
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