Publication
Title
Possible role for **ENPP1** polymorphism in obesity but not for **INSIG2** and **PLIN** variants
Author
Abstract
Previous studies have suggested that ENPP1, INSIG2, and PLIN may be linked with a higher risk for obesity or with increased phenotypic measures of obesity. We selected polymorphisms in these candidate genes based on their prior associations with obesity risk or obesity parameters. K121Q (rs1044498) in ENPP1, rs7566605 in INSIG2, and rs894160 in PLIN were genotyped by Taqman assays in a Belgian sample of 1,078 obese subjects (body mass index (BMI) > 30 kg/m(2)) and 323 lean controls (18.5 < BMI < 25 kg/m(2)). BMI, waist circumference, and waist-to-hip ratio (WHR) were assessed by standard methods while a computerized tomography-scan was used to measure visceral (VFA), subcutaneous (SFA), and total (TFA) abdominal fat areas. Presence of the rare allele was not significantly different between cases and controls for the three variants that were tested, while only WHR was associated with ENPP1 in obese subjects. Our data thus indicate that K121Q, rs7566605, and rs894160 are not major contributing factors for obesity.
Language
English
Source (journal)
Endocrine. - Totowa, N.J.
Publication
Totowa, N.J. : 2009
ISSN
0969-711X
Volume/pages
36:1(2009), p. 103-109
ISI
000267781000017
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 25.08.2009
Last edited 12.06.2017
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