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Title
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Central nervous system invasion by community-acquired meticillin-resistant **Staphylococcus aureus**
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Author
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Abstract
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| We report a case of community-acquired meticillin-resistant Staphylococcus aureus (CA-MRSA) bacteraemia with cavernous sinus thrombosis, meningitis and brain abscess in a previously healthy American, who was employed in Belgium. We consecutively reviewed all published cases of CA-MRSA with central nervous system (CNS) involvement. A total of 12 similar cases were found, of which 11 were published in the last 4 years. Predominantly, young previously healthy subjects were affected (median age 28 years). The cases involved brain abscesses (5/12), disseminated disease (4/12), cavernous sinus thrombosis (2/12) and other (1/12). Infection origins were superficial skin infections (5/12), mostly of the face, sinusitis (1/12), otitis media (1/12), other or unknown (5/12). Although, in our review of the literature patients treated with linezolid had a better outcome compared to patients treated with vancomycin, the latter is still the mainstay of therapy for CNS infections associated with MRSA. |
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Language
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English
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Source (journal)
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Journal of medical microbiology. - Edinburgh, 1968, currens
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Publication
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Edinburgh
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2009
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ISSN
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0022-2615
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DOI
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10.1099/JMM.0.011130-0
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Volume/pages
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58
:9
(2009)
, p. 1247-1251
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ISI
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000269676200020
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Full text (Publisher's DOI)
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