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Title
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Synthesis of functionalized pyridazin-3(2**H**)-ones via bromine-magnesium exchange on bromopyridazin-3(2**H**)-ones
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Author
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Abstract
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| The potential of halogen−magnesium exchange reactions, followed by quenching with electrophiles, for the functionalization of the pyridazin-3(2H)-one core was investigated. 2-Benzyl-4-bromo-5-methoxy- (1), 2-benzyl-5-bromo-4-methoxy- (4), and 2-benzyl-4,5-dibromopyridazin-3(2H)-one (10) were selected as readily available model substrates. While 1 and 10 gave exclusively C-4 metalation, a tandem reaction involving nucleophilic substitution via addition elimination and bromine−magnesium exchange was observed with 4. |
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Language
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English
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Source (journal)
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The journal of organic chemistry. - Washington, D.C., 1936, currens
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Publication
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Washington, D.C.
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2009
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ISSN
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0022-3263
[print]
1520-6904
[online]
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DOI
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10.1021/JO9020985
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Volume/pages
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74
:24
(2009)
, p. 9440-9445
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ISI
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000272462100025
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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