Publication
Title
Synthesis of functionalized pyridazin-3(2**H**)-ones via bromine-magnesium exchange on bromopyridazin-3(2**H**)-ones
Author
Abstract
The potential of halogen−magnesium exchange reactions, followed by quenching with electrophiles, for the functionalization of the pyridazin-3(2H)-one core was investigated. 2-Benzyl-4-bromo-5-methoxy- (1), 2-benzyl-5-bromo-4-methoxy- (4), and 2-benzyl-4,5-dibromopyridazin-3(2H)-one (10) were selected as readily available model substrates. While 1 and 10 gave exclusively C-4 metalation, a tandem reaction involving nucleophilic substitution via addition elimination and bromine−magnesium exchange was observed with 4.
Language
English
Source (journal)
The journal of organic chemistry. - Washington, D.C.
Publication
Washington, D.C. : 2009
ISSN
0022-3263
Volume/pages
74:24(2009), p. 9440-9445
ISI
000272462100025
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 25.11.2009
Last edited 18.06.2017
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