Title
|
|
|
|
Ellagic acid derivatives from **Syzygium cumini** stem bark: investigation of their antiplasmodial activity
| |
Author
|
|
|
|
| |
Abstract
|
|
|
|
Bioguided fractionation of Syzygium cumini (Myrtaceae) bark decoction for antiplasmodial activity was performed, leading to the isolation of three known ellagic acid derivatives (ellagic acid, ellagic acid 4-O-alpha-L-2"-acetylrhamnopyranoside, 3-O-methylellagic acid 3'-O-alpha-L-rhamnopyranoside), as well as the new derivative 3-O-methylellagic acid 3'-O-beta-D-glucopyranoside. Activity investigation was based on the reduction of P. falciparum (PfK1) parasitaemia in vitro and the inhibition of beta-hematin formation, a known mechanism of action of some antimalarial drugs. Among the investigated ellagic acid derivatives, only ellagic acid was able to reduce P. falciparum parasitaemia in vitro and inhibit beta-hematin formation, suggesting that free hydroxyl groups are necessary for activity within this class of compounds. |
| |
Language
|
|
|
|
English
| |
Source (journal)
|
|
|
|
NATURAL PRODUCT COMMUNICATIONS
| |
Publication
|
|
|
|
2009
| |
ISSN
|
|
|
|
1934-578X
| |
Volume/pages
|
|
|
|
4
:10
(2009)
, p. 1371-1376
| |
ISI
|
|
|
|
000270962600012
| |
|