Publication
Title
Chemoradiation interactions under reduced oxygen conditions: cellular characteristics of an **in vitro** model
Author
Abstract
Hypoxic tumour regions often contain viable cells that are more resistant to chemotherapy and/or radiotherapy, making it of key importance to analyse new combination treatments under both normoxic and hypoxic conditions. In this study, the impact of moderate hypoxia and anoxia on cellular characteristics was investigated in isogenic A549 cells differing in p53 status. VEGF expression, doubling time, cell cycle distribution, induction of apoptosis and p53 protein expression were evaluated. Radiation survival curves yielded an oxygen enhancement ratio of 1.161.67. In conclusion, an in vitro hypoxia model that will be highly useful to analyse chemoradiation interactions is presented.
Language
English
Source (journal)
Cancer letters. - Amsterdam
Publication
Amsterdam : 2009
ISSN
0304-3835
Volume/pages
286:2(2009), p. 180-188
ISI
000272576400005
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 16.12.2009
Last edited 19.06.2017
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