Title
Clinical applications of image-based airway computational fluid dynamics: assessment of inhalation medication and endobronchial devicesClinical applications of image-based airway computational fluid dynamics: assessment of inhalation medication and endobronchial devices
Author
Faculty/Department
Faculty of Sciences. Physics
Faculty of Medicine and Health Sciences
Research group
Biophysics and Biomedical Physics
Condensed Matter Theory
Antwerp Surgical Training, Anatomy and Research Centre (ASTARC)
Laboratory Experimental Medicine and Pediatrics (LEMP)
Publication type
article
Publication
Subject
Human medicine
Source (journal)
Proceedings of SPIE
Volume/pages
7262(2009), p. 72621P,1-72621P,9
ISSN
0277-786X
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Computational fluid dynamics (CFD) is a technique that is used increasingly in the biomedical field. Solving the flow equations numerically provides a convenient way to assess the efficiency of therapies and devices, ranging from cardiovascular stents and heart valves to hemodialysis workflows. Also in the respiratory field CFD has gained increasing interest, especially through the combination of three dimensional image reconstruction which results in highend patient-specific models. This paper provides an overview of clinical applications of CFD through image based modeling, resulting from recent studies performed in our center. We focused on two applications: assessment of the efficiency of inhalation medication and analysis of endobronchial valve placement. In the first application we assessed the mode of action of a novel bronchodilator in 10 treated patients and 4 controls. We assessed the local volume increase and resistance change based on the combination of imaging and CFD. We found a good correlation between the changes in volume and resistance coming from the CFD results and the clinical tests. In the second application we assessed the placement and effect of one way endobronchial valves on respiratory function in 6 patients. We found a strong patientspecific result of the therapy where in some patients the therapy resulted in complete atelectasis of the target lobe while in others the lobe remained inflated. We concluded from these applications that CFD can provide a better insight into clinically relevant therapies.
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