Angioedema beyond histamine: an educational case series
Faculty of Medicine and Health Sciences
Acta clinica Belgica. - Leuven, 1946 - 1997
, p. 520-528
University of Antwerp
Angioedema constitutes an important clinical problem that can cause signifi cant morbidity and mortality. Correct management requires a prompt recognition and treatment of the acute event and identification of the underlying cause. Many cases are caused by non-allergic reactions and do not result from mediator release by degranulating mast cells and basophils, but are related to accumulation of plasma and tissue bradykinin. This case series aims primarily to describe some important causes of non-allergic bradykinin-induced angioedema. Particular emphasis is put on clinical particularities, differential diagnosis, diagnostic approach and correct therapeutic management, as bradykinin-mediated angioedema is unresponsive to antihistamines.