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Title
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A manually curated network of the PML nuclear body interactome reveals an important role for PML-NBs in SUMOylation dynamics
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Author
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Abstract
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| Promyelocytic Leukaemia Protein nuclear bodies (PML-NBs) are dynamic nuclear protein aggregates. To gain insight in PML-NB function, reductionist and high throughput techniques have been employed to identify PML-NB proteins. Here we present a manually curated network of the PML-NB interactome based on extensive literature review including database information. By compiling the PML-ome, we highlighted the presence of interactors in the Small Ubiquitin Like Modifier (SUMO) conjugation pathway. Additionally, we show an enrichment of SUMOylatable proteins in the PML-NBs through an in-house prediction algorithm. Therefore, based on the PML network, we hypothesize that PML-NBs may function as a nuclear SUMOylation hotspot. |
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Language
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English
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Source (journal)
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International journal of biological sciences
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Publication
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2010
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ISSN
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1449-2288
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Volume/pages
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6
:1
(2010)
, p. 51-67
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ISI
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000274663800003
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Full text (Publisher's DOI)
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Full text (open access)
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