Title
A manually curated network of the PML nuclear body interactome reveals an important role for PML-NBs in SUMOylation dynamicsA manually curated network of the PML nuclear body interactome reveals an important role for PML-NBs in SUMOylation dynamics
Author
Faculty/Department
Faculty of Sciences. Mathematics and Computer Science
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Research group
Algebra, geometry and ISLAb
Proteinchemistry, proteomics and epigenetic signalling(PPES)
Publication type
article
Publication
Subject
Biology
Human medicine
Source (journal)
International journal of biological sciences
Volume/pages
6(2010):1, p. 51-67
ISSN
1449-2288
ISI
000274663800003
Carrier
E
Target language
English (eng)
Affiliation
University of Antwerp
Abstract
Promyelocytic Leukaemia Protein nuclear bodies (PML-NBs) are dynamic nuclear protein aggregates. To gain insight in PML-NB function, reductionist and high throughput techniques have been employed to identify PML-NB proteins. Here we present a manually curated network of the PML-NB interactome based on extensive literature review including database information. By compiling the PML-ome, we highlighted the presence of interactors in the Small Ubiquitin Like Modifier (SUMO) conjugation pathway. Additionally, we show an enrichment of SUMOylatable proteins in the PML-NBs through an in-house prediction algorithm. Therefore, based on the PML network, we hypothesize that PML-NBs may function as a nuclear SUMOylation hotspot.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/3bc068/9db05473.pdf
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