Publication
Title
Evaluation of cell death markers in severe calcified aortic valves
Author
Abstract
Degenerative aortic valve disease is the most frequent acquired valve disease. Especially in the elderly, its prevalence is increasing. Once the disease becomes symptomatic, it is rapidly fatal. The disease cannot be considered a result of aging alone. The condition is an active process, which occurs with rapid progression, especially when calcification can be documented. This calcification can be the end result of cellular mechanisms involving cell death pathways (such as autophagy) and cellular matrix remodeling. These processes are beginning to be unraveled in the initiation and propagation of the disease. Autophagy could be the common step through which these mechanisms lead to this pathway of cell death in this disease. Autophagy can be detected by procedures described hereafter.
Language
English
Source (journal)
Methods in enzymology. - New York, N.Y.
Publication
New York, N.Y. : 2009
ISSN
0076-6879
Volume/pages
453(2009), p. 365-378
ISI
000263827100018
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 15.01.2010
Last edited 17.09.2017
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