Title
Comparing isotropic and anisotropic smoothing for voxel-based DTI analyses : a simulation study Comparing isotropic and anisotropic smoothing for voxel-based DTI analyses : a simulation study
Author
Faculty/Department
Faculty of Sciences. Physics
Faculty of Medicine and Health Sciences
Publication type
article
Publication
New York ,
Subject
Physics
Source (journal)
Human brain mapping: a journal devoted to functional neuroanatomy and neuroimaging. - New York
Volume/pages
31(2010) :1 , p. 98-114
ISSN
1065-9471
ISI
000273544700009
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Voxel-based analysis (VBA) methods are increasingly being used to compare diffusion tensor image (DTI) properties across different populations of subjects. Although VBA has many advantages, its results are highly dependent on several parameter settings, such as those from the coregistration technique applied to align the data, the smoothing kernel, the statistics, and the post-hoc analyses. In particular, to increase the signal-to-noise ratio and to mitigate the adverse effect of residual image misalignments, DTI data are often smoothed before VBA with an isotropic Gaussian kernel with a full width half maximum up to 16 × 16 × 16 mm3. However, using isotropic smoothing kernels can significantly partial volume or voxel averaging artifacts, adversely affecting the true diffusion properties of the underlying fiber tissue. In this work, we compared VBA results between the isotropic and an anisotropic Gaussian filtering method using a simulated framework. Our results clearly demonstrate an increased sensitivity and specificity of detecting a predefined simulated pathology when the anisotropic smoothing kernel was used.
E-info
https://repository.uantwerpen.be/docman/iruaauth/22ad25/c6162bc6926.pdf
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