Title
Monosensitivity to pangasius and tilapia caused by allergens other than parvalbuminMonosensitivity to pangasius and tilapia caused by allergens other than parvalbumin
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Research group
Translational Pathophysiological Research (TPR)
Faculteit Geneeskunde
Publication type
article
Publication
Barcelona,
Subject
Human medicine
Source (journal)
Journal of investigational allergology & clinical immunology : official organ of the International Association of Asthmology (INTERASMA) and Sociedad Latinoamericana de Alergia e Inmunologia / International Association of Asthmology. - Barcelona
Volume/pages
20(2010):1, p. 84-88
ISSN
1018-9068
ISI
000274938800013
Carrier
E
Target language
English (eng)
Affiliation
University of Antwerp
Abstract
Fish allergy is one of the most common food allergies in populations where fish is a major part of the diet. Most fi sh-allergic patients react to the panallergen parvalbumin present in multiple fi sh species. Our aim was to investigate the clinical case of a patient with oral allergy syndrome to pangasius and Nile tilapia but tolerance of other fi sh and seafood. The temporal relationship between fi sh consumption and allergic symptoms, the positive skin prick tests, and the basophil activation test results for both fi sh species strongly supported the diagnosis of an immunoglobulin (Ig) E-mediated allergy. This was confi rmed by the detection of specifi c IgE to 18-kDa and 45-kDa proteins in immunoblot analysis. Notably, the patient was not sensitized to parvalbumin, as shown by enzyme-linked immunosorbent assay using purified allergens. Cross-reactivity between fi sh species can result from sensitization to allergens other than parvalbumin. This case report emphasizes the applications of fl ow cytometry-assisted analysis in the diagnosis of food allergy.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/0de4f0/9b467e07.pdf
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