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Title
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Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate
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Author
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Abstract
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| We conducted a genome-wide association study for nonsyndromic cleft lip with or without cleft palate (NSCL/P) in 401 affected individuals and 1,323 controls, with replication in an independent sample of 793 NSCL/P triads. We report two new loci associated with NSCL/P at 17q22 (rs227731, combined P = 1.07 × 10−8, relative risk in homozygotes = 1.84, 95% CI 1.342.53) and 10q25.3 (rs7078160, combined P = 1.92 × 10−8, relative risk in homozygotes = 2.17, 95% CI 1.323.56). |
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Language
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English
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Source (journal)
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Nature genetics. - New York, N.Y.
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Publication
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New York, N.Y.
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2010
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ISSN
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1061-4036
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DOI
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10.1038/NG.506
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Volume/pages
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42
:1
(2010)
, p. 24-26
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ISI
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000273055100011
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Full text (Publisher's DOI)
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