Publication
Title
Generation of Merkel cell polyomavirus virus-like particles and their application to the detection of MCV antibodies
Author
Abstract
The genome of a new human polyomavirus, known as Merkel cell polyomavirus (MCV), has recently been reported to be integrated within the cellular DNA of Merkel cell carcinoma (MCC), a rare human skin cancer. To investigate MCV seroprevalence in the general population, we expressed three different MCV VP1 in insect cells using recombinant baculoviruses. Virus-like particles were obtained with only one of the three VP1 genes. High titer antibodies against VP1 VLPs were detected in mice immunized with MCV VLPs and limited cross-reactivity was observed with BKV and LPV. MCV antibodies were detected in 77% of the general population, with variations according to age.
Language
English
Source (journal)
Journal of clinical microbiology. - Washington, D.C.
Publication
Washington, D.C. : 2010
ISSN
0095-1137
Volume/pages
48:5(2010), p. 1767-1770
ISI
000277356600040
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 02.03.2010
Last edited 04.08.2017
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