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Title
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ATP synthase inhibition of **Mycobacterium avium** is not bactericidal
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Author
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Abstract
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| The efficacy of ATP synthase inhibitor TMC207 was assessed in early and late Mycobacterium avium infections in mice. In contrast to what was earlier observed for M. tuberculosis, a bacteriostatic effect was obtained. In vitro, the minimal bactericidal concentration (MBC)/MIC ratio was very high. The MBC was more relevant for assessment of pharmacokinetic/pharmacodynamic relationships than the MIC. |
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Language
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English
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Source (journal)
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Antimicrobial agents and chemotherapy. - Washington, D.C., 1972, currens
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Publication
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Washington, D.C.
:
American Society for Microbiology
,
2009
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ISSN
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0066-4804
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DOI
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10.1128/AAC.00689-09
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Volume/pages
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53
:11
(2009)
, p. 4927-4929
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ISI
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000270881200051
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Full text (Publisher's DOI)
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