Title
ATP synthase inhibition of **Mycobacterium avium** is not bactericidal ATP synthase inhibition of **Mycobacterium avium** is not bactericidal
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Publication type
article
Publication
Washington, D.C. ,
Subject
Human medicine
Source (journal)
Antimicrobial agents and chemotherapy. - Washington, D.C.
Volume/pages
53(2009) :11 , p. 4927-4929
ISSN
0066-4804
ISI
000270881200051
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
The efficacy of ATP synthase inhibitor TMC207 was assessed in early and late Mycobacterium avium infections in mice. In contrast to what was earlier observed for M. tuberculosis, a bacteriostatic effect was obtained. In vitro, the minimal bactericidal concentration (MBC)/MIC ratio was very high. The MBC was more relevant for assessment of pharmacokinetic/pharmacodynamic relationships than the MIC.
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