Publication
Title
Essentiality of FASII pathway for **Staphylococcus aureus**
Author
Abstract
Recently, Brinster et al. 1 suggested that type II fatty-acid biosynthesis (FASII) is not a suitable antibacterial target for Gram-positive pathogens because they use fatty acids directly from host serum rather than de novo synthesis. Their findings, if confirmed, are relevant for further scientific and financial investments in the development of new drugs targeting FASII. We present here in vitro and in vivo data demonstrating that their observations do not hold for Staphylococcus aureus, a major Gram-positive pathogen causing several human infections. The observed differences among Gram-positive pathogens in FASII reflects heterogeneity either in fatty-acid synthesis or in the capacity for fatty-acid uptake from the environment.
Language
English
Source (journal)
Nature. - London
Publication
London : 2010
ISSN
0028-0836
Volume/pages
463:7278(2010), p. E3
ISI
000273748100055
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 12.03.2010
Last edited 09.09.2017
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