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Title
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More advanced Alzheimer's disease may be associated with a decrease in cerebrospinal fluid pressure
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Author
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Abstract
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| In a recent article, elevated cerebrospinal fluid pressure (CSFP) consistent with very early normal pressure hydrocephalus (NPH), was found in a small subset of Alzheimer's disease (AD) patients (possible AD-NPH hybrids) enrolled in a clinical trial for chronic low-flow cerebrospinal fluid drainage. Also in the same study, was another interesting finding that merits further discussion: a substantial proportion of AD patients had very low CSFP. Based on the characteristics of these subjects, we hypothesize that more advanced AD may be associated with a decrease in CSFP. Reduced CSFP among a group of AD patients could provide a clue towards a better understanding of the high rate of comorbidity reported between AD and glaucoma since it has been shown that mean CSFP is lower in subjects with primary open-angle glaucoma. This could result in an abnormally high trans-lamina cribrosa pressure difference and lead to glaucomatous damage. |
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Language
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English
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Source (journal)
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Cerebrospinal fluid research. - London
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Publication
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London
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2009
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ISSN
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1743-8454
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Volume/pages
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6
(2009)
, p. 14,1-14,3
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Full text (Publisher's DOI)
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Full text (open access)
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