|
Title
|
|
|
|
Neurobiochemical markers of brain damage in cerebrospinal fluid of acute ischemic stroke patients
| |
|
Author
|
|
|
|
| |
|
Abstract
|
|
|
|
| Background: Ischemic injury to the central nervous system causes cellular activation and disintegration, leading to release of cell-typespecific proteins into the cerebrospinal fluid (CSF). We investigated CSF concentrations of myelin basic protein (MBP), glial fibrillary astrocytic protein (GFAP), the calcium-binding protein S100B, and neuron-specific enolase (NSE) in acute ischemic stroke patients and their relation to initial stroke severity, stroke location, and long-term stroke outcome. Methods: CSF concentrations of MBP, GFAP, S100B, and NSE were assessed in 89 stroke patients on admission (mean 8.7 h after stroke onset) and in 35 controls. We evaluated the relation between CSF concentrations and (a) stroke severity (NIH Stroke Scale [NIHSS] score on admission, infarct volume), (b) stroke location, and (c) stroke outcome (modified Rankin Scale [mRS] score at month 3). Results: MBP concentration was significantly higher in subcortical than in cortical infarcts (median MBP, 1.18 vs 0.66 µg/L, P < 0.001). GFAP and S100B concentrations correlated with the NIHSS score on admission (GFAP, R = 0.35, P = 0.001; S100B, R = 0.29, P = 0.006), infarct volume (GFAP, R = 0.34, P = 0.001; S100B, R = 0.28, P = 0.008), and mRS score at month 3 (R = 0.42, P < 0.001 and R = 0.28, P = 0.007). Concentrations of NSE did not correlate with stroke characteristics. Conclusions: MBP, GFAP, S100B, and NSE display relevant differences in cellular and subcellular origins, which are reflected in their relation to stroke characteristics. MBP is a marker for infarct location. GFAP and S100B correlate with stroke severity and outcome. |
| |
|
Language
|
|
|
|
English
| |
|
Source (journal)
|
|
|
|
Clinical chemistry : international journal of laboratory medicine and molecular diagnostics / American Association of Clinical Chemists. - Winston-Salem, N.C., 1955, currens
| |
|
Publication
|
|
|
|
Winston-Salem, N.C.
:
2010
| |
|
ISSN
|
|
|
|
0009-9147
[print]
1530-8561
[online]
| |
|
DOI
|
|
|
|
10.1373/CLINCHEM.2009.134122
| |
|
Volume/pages
|
|
|
|
56
:3
(2010)
, p. 451-458
| |
|
ISI
|
|
|
|
000275392000022
| |
|
Full text (Publisher's DOI)
|
|
|
|
| |
|