Publication
Title
**In vitro** activities of plant extracts from Saudi Arabia against malaria, leishmaniasis, sleeping sickness and Chagas disease
Author
Abstract
The in vitro activity of the methanol extracts of 51 plants randomly collected from the Kingdom of Saudi Arabia and some of their fractions (petroleum ether, chloroform, ethyl acetate and aqueous) were evaluated against Plasmodium falciparum, Trypanosoma brucei brucei, T. cruzi and Leishmania infantum, as well as toxicity against MRC-5 fibroblast cells. Ten crude methanolic extracts that demonstrated potent and adequately selective antiprotozoal activity were subjected to solvent fractionation using petroleum ether, ethyl acetate and chloroform. Only three samples showed promising antiprotozoal activity. Argemone ochroleuca (CHCl3 fraction) showed pronounced activity against P. falciparumGHA (IC50 0.32 g/mL) and T. cruzi (IC50 0.30 g/mL) with low cytotoxicity against MRC-5 cells (CC50 11.6 g/mL). Capparis spinosa (EtOAc fraction) showed pronounced activity against P. falciparumGHA with an IC50 0.50 g/mL in the absence of toxicity against MRC-5 cell line (CC50 > 30 g/mL). Heliotropium curassavicum (CHCl3 fraction) showed similar activity against P. falciparum (IC50 0.65 g/mL; MRC-5 CC50 > 30 g /mL). These three extracts will be subjected for further extensive studies to isolate and identify their active constituents.
Language
English
Source (journal)
Phytotherapy research. - London
Publication
London : 2010
ISSN
0951-418X
Volume/pages
24:9(2010), p. 1322-1328
ISI
000281254900010
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 29.03.2010
Last edited 02.11.2017
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