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Title
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Follow-up study of susceptibility loci for Alzheimers disease and onset age identified by genome-wide association
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Author
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Abstract
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| Replication of genetic association findings in independent studies represents an important validation tool in the search for susceptibility genes for complex diseases such as Alzheimers disease (AD). In a well-characterized memory-clinic based study comprising 1078 unrelated AD patients and 652 control individuals, we set out to replicate previously reported genome-wide association of four novel risk SNPs with AD and onset age, with first stage p-values ranging from 0.001 to 0.000004. We obtained evidence for association between rs179943, an intronic SNP in ATXN1 at 6p22.3, and affection status (OR = 0.63 (95% CI = 0.440.90; nominal p = 0.01)). Overall, our data provided independent support for association of at least one chromosomal locus with AD and warranted a more in-depth investigation of these regions for possible underlying functional variants. |
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Language
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English
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Source (journal)
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Journal of Alzheimer's disease. - -
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Publication
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2010
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ISSN
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1387-2877
1875-8908
[Electronic]
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DOI
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10.3233/JAD-2010-1310
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Volume/pages
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19
:4
(2010)
, p. 1169-1175
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ISI
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000276619700007
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Full text (Publisher's DOI)
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