Title
The **SCN1A** variant database: a novel research and diagnostic tool The **SCN1A** variant database: a novel research and diagnostic tool
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
New York, N.Y. ,
Subject
Human medicine
Source (journal)
Human mutation. - New York, N.Y.
Volume/pages
30(2009) :10 , p. E904-E920
ISSN
1059-7794
ISI
000279980600002
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
The neuronal voltage-gated sodium channel Nav1.1 encoded by the SCN1A gene plays an important role in the generation and propagation of action potentials in the central nervous system. Altered function of this channel due to mutations in SCN1A leads to hypersynchronous neuronal discharges resulting in seizures or migrainous attaques. A large number of distinct sequence variants in SCN1A are associated with diverse epilepsy and migraine syndromes. We developed an online and freely available database containing all reported sequence variants in SCN1A (http://www.molgen.ua.ac.be/SCN1AMutations/). We verified 623 distinct sequence variants, listed them using standard nomenclature for description and classified them according to their putative pathogenic nature. We provided links to relevant publications and information on the associated phenotype. The database can be queried using cDNA or protein position, phenotype, variant type or publication. By listing all SCN1A variants in a comprehensive manner, this database will facilitate interpretation of newly identified sequence variants and provide better insight into the genotype-phenotype relations of the growing number of SCN1A mutations.
E-info
https://repository.uantwerpen.be/docman/iruaauth/570658/cdebba8a7b8.pdf
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