Title
Epoetin delta reduces oxidative stress in primary human renal tubular cellsEpoetin delta reduces oxidative stress in primary human renal tubular cells
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Research group
Pathophysiology
Publication type
article
Publication
New York, N.Y.,
Subject
Biology
Human medicine
Source (journal)
Journal of biomedicine and biotechnology. - New York, N.Y.
Volume/pages
2010(2010), p. 395785,1-395785,9
ISSN
1110-7243
ISI
000278458700001
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Erythropoietin (EPO) exerts (renal) tissue protective effects. Since it is unclear whether this is a direct effect of EPO on the kidney or not, we investigated whether EPO is able to protect human renal tubular epithelial cells (hTECs) from oxidative stress and if so which pathways are involved. EPO (epoetin delta) could protect hTECs against oxidative stress by a dose-dependent inhibition of reactive oxygen species formation. This protective effect is possibly related to the membranous expression of the EPO receptor (EPOR) since our data point to the membranous EPOR expression as a prerequisite for this protective effect. Oxidative stress reduction went along with the upregulation of renoprotective genes. Whilst three of these, heme oxygenase-1 (HO-1), aquaporin-1 (AQP-1), and B-cell CLL/lymphoma 2 (Bcl-2) have already been associated with EPO-induced renoprotection, this study for the first time suggests carboxypeptidase M (CPM), dipeptidyl peptidase IV (DPPIV), and cytoglobin (Cygb) to play a role in this process.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/df6f5e/ab255d2c.pdf
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