Title
Morphologic and functional changes in the unilateral 6-hydroxydopamine lesion rat model for Parkinsons disease discerned with <tex>$\mu$</tex>SPECT and quantitative MRIMorphologic and functional changes in the unilateral 6-hydroxydopamine lesion rat model for Parkinsons disease discerned with <tex>$\mu$</tex>SPECT and quantitative MRI
Author
Faculty/Department
Faculty of Sciences. Physics
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Research group
Bio-Imaging lab
Vision lab
Publication type
article
Publication
New York,
Subject
Veterinary medicine
Human medicine
Computer. Automation
Source (journal)
Magnetic resonance materials in physics, biology, and medicine. - New York
Volume/pages
23(2010):2, p. 65-75
ISSN
1352-8661
0968-5243
ISI
000276723000001
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
In the present study, we aimed to evaluate the impact of neurodegeneration of the nigrostriatal tract in a rodent model of Parkinson's disease on the different MR contrasts (T(2), T(1), CBF and CBV) measured in the striatum. Animals were injected with 6-hydroxydopamine (6OHDA) in the substantia nigra resulting in massive loss of nigrostriatal neurons and hence dopamine depletion in the ipsilateral striatum. Using 7T MRI imaging, we have quantified T(2), T(1), CBF and CBV in the striata of 6OHDA and control rats. To validate the lesion size, behavioral testing, dopamine transporter mu SPECT and tyrosine hydroxylase staining were performed. No significant differences were demonstrated in the absolute MRI values between 6OHDA animals and controls; however, 6OHDA animals showed significant striatal asymmetry for all MRI parameters in contrast to controls. These PD-related asymmetry ratios might be the result of counteracting changes in both intact and affected striatum and allowed us to diagnose PD lesions. As lateralization is known to occur also in PD patients and might be expected in transgenic PD models as well, we propose that MR-derived asymmetry ratios in the striatum might be a useful tool for in vivo phenotyping of animal models of PD.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/6291b7/1988.pdf
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